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LeonardFem

Дата: Суббота, 29.11.2014, 23:08 | Сообщение # 1

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Сообщений: 3

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Автор - LeonardFem
Дата добавления - 29.11.2014 в 23:08

OrvilleOa

Дата: Воскресенье, 29.05.2016, 12:47 | Сообщение # 2

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OrvilleOa

Дата: Понедельник, 30.05.2016, 02:33 | Сообщение # 3

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OrvilleOa

Дата: Понедельник, 30.05.2016, 17:29 | Сообщение # 4

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OrvilleOa

Дата: Среда, 01.06.2016, 02:48 | Сообщение # 5

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OrvilleOa

Дата: Среда, 01.06.2016, 17:38 | Сообщение # 6

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Internet_Trucos_Jaw

Дата: Четверг, 02.06.2016, 02:32 | Сообщение # 7

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Автор - Internet_Trucos_Jaw
Дата добавления - 02.06.2016 в 02:32

OrvilleOa

Дата: Четверг, 02.06.2016, 19:10 | Сообщение # 8

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OrvilleOa

Дата: Суббота, 04.06.2016, 04:09 | Сообщение # 9

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kloreehq

Дата: Понедельник, 13.06.2016, 17:02 | Сообщение # 10

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MishaOa

Дата: Среда, 15.06.2016, 17:26 | Сообщение # 11

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Aleksandrbut

Дата: Среда, 15.06.2016, 23:55 | Сообщение # 12

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DmitriyLAK

Дата: Суббота, 18.06.2016, 22:21 | Сообщение # 13

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tcsgroupo

Дата: Пятница, 01.07.2016, 14:02 | Сообщение # 14

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СообщениеDocetaxel (as generic or subservient to the shoppers specify Taxotere) is a clinically set anti-mitotic chemotherapy medication (medication which interferes with stall compartmentation). It is worn mostly to the treatment of mamma, ovarian, prostate, and non-small cell lung cancer.<> - <> - <> - Docetaxel has an FDA approved call for after treatment of patients who partake of locally advanced, or metastatic heart of hearts or non small-cell lung cancer who procure undergone anthracycline-based chemotherapy and failed to put an end cancer chain or relapsed<> - and a European imprimatur to work in hormone-refractory prostate cancer.<> -
According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks as a rule in excess of a ten cycle despatch, docetaxel is considered as or more effective than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - However the effectiveness of docetaxel versus paclitaxel and other taxanes is undisturbed controversial. Diverse more brand-new articles father build "no evidence that regimens containing docetaxel yield greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution list hardened to be and is stationary considered compelling but hip studies are indicating a weekly plan authority be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly government has emerged as the optimal schedule." Docetaxel is marketed worldwide directed the identify Taxotere nearby Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.<citation>
Nature
Docetaxel is of the chemotherapy pharmaceutical savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Owed to inadequateness of paclitaxel, vast research was carried absent from primary to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and promptly ready European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string instead of the benzyl amide in paclitaxel. The carbon 10 practical sort exchange causes docetaxel to be more sea water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a white powder and is the working ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a discernibly brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a singular dosage Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose for administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and reliable vials are combined to provide a solution of 10 mg/mL and the required dose is haggard from this solution. Vials be suffering with an overfill to even up for flowing harm during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored to 24 months below 25 °C away from understanding and 80 mg vials respecting 26 months in the yet conditions.<> -
Recently Sanofi has got authorization because of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion solution is simplified during eliminating the fundamental dilution step. The two-vial and one-vial formulations carry the unaltered dose theme, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the despite the fact psychedelic nub in the same concentration as the already approved two-vial formulation. The unmodified level, standing, and volume of polysorbate 80 are put on show in the infusion revelation of both formulations. The solely difference between these two formulations is the sum of ethanol.
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Автор - tcsgroupo
Дата добавления - 01.07.2016 в 14:02

ElfredaTabs

Дата: Понедельник, 11.07.2016, 00:48 | Сообщение # 15

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